No cases of fever were found in clinical trials of sublingual desensitization therapy with Changdi, or in six years of clinical use. Searches of academic databases have not found any reports of fever due to immunotherapy. If a patient is found to be febrile during the use of Changdi, he or she should be seen in the relevant outpatient clinic to control the condition. A detailed examination should then be performed to confirm whether the fever is due to a cause that routinely causes fever (e.g., respiratory infection). Because children’s immune system is not fully mature and fluctuates a lot, it is normal to have a fever due to infection if the resistance happens to be poor during the use of Changdi, and it is fine to treat the fever as a general fever. However, if the axillary temperature exceeds 38.5 degrees, desensitization should be stopped and continued after the axillary temperature returns to below 38.5 degrees. Intolerance in sublingual desensitization therapy of Changdi generally includes some mild type I hypersensitivity reactions, which come on quickly, 15 to 30 minutes, and disappear quickly if there is no rapid aggravation, such as mild oral numbness, sleepiness, local rash, digestive discomfort, etc. No need to stop the medication or special treatment. If a moderate adverse reaction such as aggravation of rhinitis or induced asthma is found, you can use the control drug while continuing to use the drug; if the adverse reaction is not controlled, only then consider reducing or stopping the drug and continue to use the drug normally after the symptoms are controlled. In case of serious adverse reactions such as aggravation of asthma, chest reaction, systemic skin mucosal reaction, severe gastrointestinal discomfort, drop in blood pressure, etc., the drug should be discontinued immediately and controlled with intramuscular epinephrine, combined with antihistamine, bronchodilator, etc. At present, there has never been a single serious systemic adverse reaction in the normally performed sublingual desensitization therapy of Changdi.