So far there is no clear targeted drug for gallbladder cancer, and targeted drugs such as Entrectinib and Sorafenib can be used under the guidance of doctors for treatment. 1. Entrectinib is a tyrosine kinase inhibitor, which has the effect of inhibiting the growth of tumor cells and can be used to treat the discomfort caused by pancreatic cancer, bile duct cancer and other diseases. Genetic testing is required before use, and it can only be used if it has the corresponding target. Long-term use may cause fatigue, constipation, vomiting and other adverse reactions, and patients who are allergic to the drug are prohibited from using it. 2. Sorafenib is a multikinase inhibitor, which can inhibit the growth of tumor cells. It is clinically used in the treatment of inoperable advanced renal cell carcinoma and primary hepatocellular carcinoma with distant metastasis, and can be used in patients with gallbladder cancer. Skin toxicity, bleeding tendency, high blood pressure and other adverse reactions can occur with long-term use, and it is forbidden for allergic people. The drug should be used under doctor’s instruction, do not blindly use the drug or change the dosage. Rest, proper exercise and reasonable diet should be observed in daily life.