The kidney is the main cause of infertility, and the kidney is the main cause of infertility. The kidney collects essence and reproduction, and is the root of the body’s growth and development, and the root of the internal organs’ functional activities. The “Nei Jing Shanggu Tian Zhen Lun” cloud: “women seven years old, kidney gas, teeth more hair long, two seven and the day sebum to, any vein through, Taichong vein Sheng, menstruation to time down, so there are children, husband eight years old, kidney gas real, hair long teeth more, two eight kidney gas, the day sebum to, essence overflow diarrhea, Yin and Yang, so can have children, …… eight eight days of seborrhea exhaustion, less essence kidney failure …… and no children.” It can be seen that the kidneys are the main reason for the presence or absence of children, and replenishing the kidneys is the fundamental method of treating infertility. Clinically, in the treatment of infertility, tonifying the kidneys is often combined with regulating the liver, why? In terms of physiology and pathology, liver and kidney have the same origin. Kidney essence has to be constantly filled by the essence made of liver blood, and liver blood depends on the nourishment of kidney essence, and essence and blood are mutually nourishing. In the course of the meridians, the liver meridian surrounds the yin organ and passes through. The liver is the main cause of the liver’s depression, which causes the liver to lose its drainage and the blood to become unregulated, and liver depression can lead to endocrine disorders, further aggravating the condition, so the vicious cycle. The “Fu Qing master of women’s medicine” said: “Women have embraced the vegetarian evil, can not give birth to children, people think that the heart of heaven is tired of it, who knows is the liver qi stagnation! …… liver qi is depressed then the heart and kidney veins will lead to the extreme of depression and no solution. …… its depression can not become a fetus to the liver wood is not relaxed, will be down to grasp the spleen earth, and lead to plug the spleen earth gas, plug then the waist umbilical gas will be unfavorable. The gas of the umbilicus is not good, will not be able to pass the Ren vein and reach the belt vein, the gas of the belt vein is also plugged, the gas of the belt vein is plugged, the door of the twins will be closed, the essence that is to the door, but also not its door and into the carry on, what can it do? The treatment must solve the four channels of depression, in order to open the door of the twins is a few carry on.” Professor Luo Yuankai pointed out, “In addition to regulating menstruation, women should not be depressed and tense in mind. Modern psychological research shows that emotional factors can interfere with the secretory function of the hypothalamic-pituitary-ovarian axis through the cerebral cortex, resulting in ovulation disorders and endocrine dysfunction, menopause, menstrual irregularities, dysfunctional uterine bleeding, luteal insufficiency, tubal spasm, abnormal cervical mucus secretion, etc., resulting in infertility. Therefore, to treat infertility, kidney tonification should regulate the liver. From the viewpoint of clinical effect, tonifying the kidney and regulating the liver is better than simply tonifying the kidney or regulating the liver. We add Su Xin Hua, Xiang Shen, Yu Jin and other products that regulate the liver and relieve depression on the basis of tonifying the kidney as appropriate, or add Si Wei San, Dan Yuan Yi Yao San, etc., and achieve better results clinically. Under the guidance of the principle of tonifying the kidney and regulating the liver method, we composed the formula of tonifying the kidney and regulating the liver, which has achieved better effect on male hypospermia, weak sperm, female luteal insufficiency and ovulation disorder.