Itchy moles may be caused by localized damage, contact with allergic substances, or malignant changes. 1. Localized breakage: If the mole and the surrounding skin are broken, there may be redness, swelling, pain and so on, and when the lesion heals, it will lead to localized itching symptoms. 2. Contact with allergic substances: If the mole and the surrounding skin come into contact with allergens (e.g. insect hairs, pollen, dust, chemical fiber clothing, etc.) or mosquito bites, it can lead to local allergic reactions, resulting in itching, redness and swelling of the mole. 3. Malignant changes: If a mole itches and appears to increase in size, bulge and change in shape or color rapidly, it may suggest that malignant changes have occurred. In addition, since itchy moles have the possibility of malignant changes, it is recommended to consult a doctor in time to clarify the cause of the disease and then carry out targeted treatment under the guidance of the doctor.