The most useful medications for treating premature ejaculation do not exist due to large individual differences, but medications such as lidocaine, dapoxetine, doxazosin, and tramadol can be used to treat the condition. Premature ejaculation is a male sexual dysfunction that involves uncontrolled ejaculation for short periods of time. Premature ejaculation is often divided into primary premature ejaculation and secondary premature ejaculation, and often combined with other diseases triggered premature ejaculation, such as chronic prostatitis, depression and other diseases. 1. Primary premature ejaculation: generally there is no clear cause of premature ejaculation, you can follow the doctor’s instructions to use local anesthetic drugs, such as lidocaine, proparacaine and so on to prolong the ejaculation time. You can also take dapoxetine and other 5-hydroxytryptamine reuptake inhibitors. 2. secondary premature ejaculation: generally have a clear cause. Such as chronic prostatitis, depression and so on. (1) chronic prostatitis: clinical manifestations of urinary frequency, urinary urgency, urinary pain, premature ejaculation, ejaculatory pain and other symptoms. The use of central analgesics, such as tramadol, or a adrenergic blockers, such as doxazosin, terazosin, alfuzosin and other drugs can be prescribed. (2) depression: depression can also lead to premature ejaculation, such as decreased libido, premature ejaculation and other symptoms. It can be treated with 5 hydroxytryptamine reuptake inhibitors, such as dapoxetine, phthalopram, paroxetine and other drugs as prescribed by the doctor. In addition, for what medicine is most useful for premature ejaculation, it is recommended that patients go to the hospital in a timely manner, in a professional doctor to diagnose and clarify the cause of the disease, and follow the doctor’s instructions for treatment.