Depersonalization disorder is a little-recognized psychiatric disorder that causes patients to feel persistently or repeatedly depersonalized or disingenuous. Diagnostic criteria include a persistent or recurrent feeling of dissociation from mental processes or the body. In the DSM-V, this psychiatric disorder is classified as dissociative disorder; in the ICD-10, it is referred to as depersonalization-disintegrative syndrome and is classified as a separate neurotic disorder. A sense of “automatism” – experiencing life change without any experience or involvement, as if life were a scene in a movie; loss of a sense of identity; feeling disconnected from one’s own body; feeling that one’s reactions are not intentional; and difficulty relating oneself to reality, to the body, and to the world. It is difficult to relate oneself to reality and the environment; it is like dreaming and having an out-of-body experience. Occasional momentary mild depersonalization is normal; intense, severe, persistent or recurrent depersonalization is problematic. Diagnostic criteria for depersonalization disorder include (but are not limited to) a persistent or recurrent feeling of being separated from the thought process or the body. Depersonalization disorder is diagnosed only when dissociation persists and interferes with the person’s social and work functions that are essential to daily life. Giving a precise definition of the disorder through research has proven difficult, both because of the inherently subjective nature of depersonalization and the ambiguity of the language used to describe it, and because depersonalization often coincides with disintegrative disorders. Depersonalization disorders are thought to result primarily from severe catastrophic life events, including childhood sexual, physical, and psychological injuries; accidents, war, torture, intimidating attacks, and severe drug use experiences. It is not clear whether genetic factors have an effect on this; however, many neurochemical as well as hormonal alterations do exist in people with depersonalization disorder. Although the disorder is an altered experience of reality, it is not associated with a thought disorder. Individuals with depersonalization disorder are able to maintain the ability to distinguish between internal experiences and objective facts about the external world. In both intermittent and persistent depersonalization, patients are able to distinguish between reality and hallucinations at the onset, and their perception of reality remains constant. Once thought to be very rare in the general population, depersonalization disorder is now thought to occur in 1-2% of the general population over a lifetime. Although the incidence of depersonalization disorder is small, varying degrees of depersonalization are frequently encountered by most people. Depersonalization disorder is associated with early disruption of perceptual and attentional processes. There are many questions about our understanding of depersonalization. First, there is very little national coverage of this issue. Textbooks are largely undocumented, and even the most authoritative domestic reference book on psychiatry, Shen Yu, ed: Psychiatry (5th edition), does not have a chapter on depersonalization disorder (Note: The index of the book has depersonalization words corresponding to depersonalization symptoms, and schizophrenia depersonalization symptoms, respectively. The third edition of the book has a chapter on depersonalization disorders.) In this way, not having basic knowledge of depersonalization is not a barrier to the promotion exam when psychiatrists are promoted to primary care physicians. Many psychiatrists are unaware of depersonalization disorders because of the lack of literature. In fact, typical depersonalization disorders are easily identified. Typical depersonalization disorder has only depersonalization symptoms and no other psychiatric symptoms. In addition, a significant proportion of patients have an abrupt onset, and the patient can often remember clearly when the onset occurred, even though the illness has been going on for several years, and the patient can still remember whether the onset began that month and day, or even whether it was in the morning or afternoon. This feature is not present in patients with other long-term mental illnesses. Another reason why personality disintegration disorder is not recognized is the lack of effective treatment. The low incidence makes it difficult to collect sufficient samples for controlled studies of clinical treatment. Most of the treatment reports on this disorder are case reports. In fact, depersonalization disorder is not as uncommon as one might think. There are more than 1,400 followers of the Baidu posting depersonalization bar. Of course, these followers are not necessarily depersonalization disorder. According to the definition of the World Health Organization (WHO), rare diseases are diseases that affect 0.65 per 1,000 to 1,000 of the total population. If we calculate the percentage of 0.65‰, we should have more than 800,000 people with depersonalization disorder in China. Most of them do not know what help to seek. American scholars believe that the lifetime prevalence of this disease is 1-2%, and if we calculate this rate, there are tens of millions of patients in China. A number of possible options continue to be explored in clinical drug research for personality dissociative disorder, including selective 5-hydroxytryptamine reuptake inhibitors, anticonvulsants, and opioid receptor antagonists. A selective 5-hydroxytryptamine reuptake inhibitor may be prioritized as fluoxetine. The priority for anticonvulsants is lamotrigine, a drug reported abroad with many drug rashes, my experience is that the national population does not seem to have as many, but there is a lack of data from large samples. Opioid receptor antagonists, which are not available in general medical institutions, are not recommended.