Chest tightness after thyroid nodule ablation may be caused by hypothyroidism, thyroid crisis and other diseases, but also other diseases such as respiratory system, cardiovascular disease and other factors. 1. Hypothyroidism: after thyroid nodule ablation, patients may need to supplement levothyroxine sodium tablets, if the dose of the drug is insufficient, hypothyroidism may occur, which may cause chest tightness. 2. Thyroid crisis: thyroid crisis may occur after thyroid nodule ablation, which may cause chest tightness and may be accompanied by high fever, diarrhea, vomiting and other symptoms. 3. Other diseases: Diseases of cardiovascular system and respiratory system, such as bronchitis, myocardial ischemia, coronary heart disease, etc., may also cause chest tightness. Patients with chest tightness after thyroid nodule ablation are advised to go to the hospital and ask the doctor to make a judgment.