Some pregnant women may experience itching of the extremities and trunk without a cause in mid to late pregnancy, or even early pregnancy. If this is not given enough attention and jaundice follows after a few days or weeks, it is time to be on high alert because you may have a pregnancy complication – intrahepatic cholestasis of pregnancy. Intrahepatic cholestasis of pregnancy is a common disorder of liver dysfunction specific to pregnancy that occurs only in certain pregnant women, who can have recurrent jaundice when they become pregnant again, and about half of the patients have close relatives with pruritus of pregnancy. The main manifestations of the disease are pruritus and jaundice, and in a few cases it may be accompanied by digestive discomfort, such as nausea and diarrhea, but all are mild. The vast majority have no significant discomfort and are able to perform their daily tasks. Research into the etiology of intrahepatic cholestasis leading to pregnancy has not been conclusive. Most scholars believe that it is related to the increase of estrogen in women’s body after pregnancy. From some survey data, there are cases of mother-daughter and sisters with this disorder, so it is presumed that there is also a relationship with genetic factors. Pregnancy is an obvious trigger for the onset of the syndrome, and the jaundice and pruritus subside as soon as the pregnancy is terminated. According to our observations, the pruritus usually disappears about two days after delivery, the jaundice gradually recedes within seven days after delivery, and the bilirubin measurement returns to normal levels within two months after delivery, and there are no sequelae. Because of the good course of the disorder, it was once overlooked. After years of research, it has been proved that if not timely diagnosed and treated, the disease has great impact on both pregnant women and fetuses, such as the reduction of coagulation factor synthesis in pregnant women, which makes them prone to postpartum hemorrhage during delivery; the chances of miscarriage, preterm delivery, intrauterine distress of fetus, low weight baby, stillbirth and stillbirth greatly exceed those of normal pregnant women, which increases the rate of perinatal disease and mortality. Therefore, prevention and treatment of complications of this disease is one of the elements of perinatal health care. In order to make a good differential diagnosis, patients with pruritus or jaundice during pregnancy should be brought to the attention of the pregnant woman and the doctor, bed rest, low-fat diet, symptomatic treatment, and at the same time, liver function, coagulation time and serum bile acid measurement should be routinely checked and periodically reviewed to understand the dynamic situation and make good intrauterine monitoring of the fetus. After the fetus is mature, try to end the delivery before 40 weeks of pregnancy.