The appearance of warts on the tongue is mainly caused by the infection of human papillomavirus, which can be intervened by medication, physical therapy and surgical treatment. 1. medication: patients can apply immunomodulators, such as thymidine and other drugs under the guidance of the doctor for treatment. 2. Physical therapy: common methods such as laser therapy, cryotherapy and so on. 3. Surgery: For warts that can’t be removed by physical therapy, or if the warts are large in size, high-frequency electrocautery or shearing can be used, but there is a risk of proliferation and recurrence. In addition to the above treatment methods, patients should pay attention to oral hygiene, to avoid secondary infection of skin lesions during the treatment process, while avoiding oral sex and other sexual behaviors during the treatment process. The patients with acromegaly of the tongue, its condition and symptoms are different, the corresponding treatment measures, it is recommended to go to the regular hospital, under the guidance of the doctor to develop an individualized treatment plan.