Coughing and chest tightness and shortness of breath during chemotherapy may be related to cardiopulmonary function damage, chest metastasis, infection and other factors. During chemotherapy cardiopulmonary function damage, patients often show chest tightness, shortness of breath, some may have cough symptoms, timely hospitalization, myocardial enzyme spectrum, electrocardiogram and other tests, to avoid serious conditions. Chest metastasis will also show cough, chest tightness, shortness of breath, etc. Chest CT examination can be carried out to help find the lesions. If metastatic lesions are found, it often suggests that the disease has progressed during chemotherapy and the treatment program should be changed. If metastatic lesions are found, it often indicates that the disease has progressed during chemotherapy and the treatment regimen should be changed. During chemotherapy, the patient’s immunity decreases, and respiratory infections are likely to occur, manifesting coughing, chest tightness and shortness of breath.