Pharmacologic liver injury ALT200U/L is more serious, liver function impairment may be further aggravated, complicated by liver failure, hepatic encephalopathy and life-threatening. Pharmacologic liver injury is defined as liver injury induced by various types of prescription or non-prescription chemical drugs, biological agents, traditional Chinese medicines, natural medicines, etc. It is one of the most common and serious adverse drug reactions. According to the classification of drug-induced liver injury, the ALT value of 200 U/L has reached 5 times of the upper limit of normal, suggesting that the pathological type is of the hepatocellular type, with severe liver inflammation and necrosis, and is prone to complications such as hepatic failure, coagulation dysfunction, and hepatic encephalopathy, etc. It is necessary to combine with the bilirubin level and other indexes to evaluate the degree of severity. Therefore, it is recommended that patients be evaluated by a physician to adjust or discontinue medications and treat with liver-protecting drugs such as silymarin.