Quadruple drugs generally refers to the treatment of Helicobacter pylori drugs, taking quadruple drugs after stopping stomach pain and diarrhea may be due to drug side effects, intestinal flora disorders and other factors. 1. drug side effects: quadruple drugs include a proton pump inhibitor (such as omeprazole, lansoprazole, etc.), two antibiotics (such as amoxicillin + clarithromycin, amoxicillin + metronidazole and other combinations) and a bismuth, of which the proton pump inhibitor and the antibiotics of the side effects of gastric pain, diarrhea, nausea, etc., resulting in the discontinuation of the drug, the short term will also appear this symptom. 2. Intestinal flora disorders: antibiotics can not only kill Helicobacter pylori, but also affect the intestinal flora, which leads to stomach pain, diarrhea and other phenomena after stopping the drug. If the stomach pain and diarrhea are serious after stopping taking quadruple drugs, you should immediately go to the hospital, under the guidance of the doctor, standardized treatment.