With the development of medical treatment, ventricular defects are usually detected by auscultation in infancy and receive early surgical treatment with low surgical risk and good prognosis. Some children with combined large ventricular defects will be diagnosed in infancy due to recurrent pneumonia and heart failure, and if timely surgery is performed, the results are good and the pulmonary artery pressure can return to normal; however, if surgery is not performed for various reasons, after passing through infancy, these children will have increased pulmonary artery pressure and fewer pneumonias than before, and parents may think that the ventricular defect becomes small or has healed and do not go to the clinic, and the child will have further increased pulmonary artery pressure and The child may develop severe pulmonary hypertension or even Eisenmenger syndrome, where the intracardiac shunt becomes a right-to-left shunt, cyanosis develops, and the opportunity for surgery is lost. The basic principle is: on the basis of traditional cardiotonic and diuretic therapy, use targeted therapy for pulmonary hypertension (endothelin receptor antagonist – bosentan, PDE-5 inhibitor – sildenafil, prostacyclin – beriberi) to reduce pulmonary artery pressure, and depending on the improvement of oxygen saturation and other indicators (right heart catheterization if necessary to assess pulmonary If necessary, a right heart catheterization will be performed to assess the pulmonary resistance) to determine whether surgery is indicated. In some children, after diagnostic treatment, oxygen saturation rose above 95%, pulmonary blood increased on chest radiographs, and ultrasound suggested a left-to-right shunt, with satisfactory mid-term results after surgical treatment.