Allergen Testing
The occurrence and development of many clinical skin diseases are related to exposure to allergens. Most patients with allergic diseases are usually treated for symptom relief without finding the real cause of the allergy, and therefore cannot do targeted prevention and treatment, resulting in repeated aggravation and prolongation of the disease.
Therefore, it is recommended that patients with frequent allergies must undergo allergen screening tests to find out whether contact, ingestion or inhalation allergens are causing the allergic reactions in order to solve the problem at the root. Never treat allergies as a minor problem and ignore the examination and treatment, which eventually leads to serious consequences.
Enzyme immunoassay is used to detect allergens quickly, accurately and painlessly. This method allows qualitative and quantitative detection of allergens (total IgE, total IgG, specific IgE, etc.) in the patient’s serum or plasma. IVT is used to detect IgE-mediated tachyphylaxis, which has a distinct seasonal pattern with a short onset and high incidence of allergic reactions. This test solves the difficulty that conventional skin tests are not suitable for detecting allergens in patients with type I allergic reactions during the attack period.
FIgG is used to detect delayed-onset allergic reactions. The reaction is mainly food-related, i.e. food intolerance. It manifests itself as a few days or a week after exposure to the allergen before the onset of the associated symptoms. These allergic reactions are often misdiagnosed due to a lag in symptoms and manifest clinically as chronic symptoms in various systems. If the cause is unknown for a long period of time, recurrent and untreated, it is recommended that food IgG should be checked.
Allergen screening test for people: patients with unknown causes of allergies, eczema, urticaria, allergic rhinitis, asthma, psoriasis and other patients should do a little allergen testing, which can be of great help in the prevention and treatment of diseases.
Allergen testing kits currently used by various hospitals can be broadly divided into these: 1, inhalant allergen screening test; 2, inhalant allergen screening test; 3, inhalant allergen classification test (this kit can find out the specific inhalant substances that cause allergic reactions such as dust mites, pollen, etc.); 4, inhalant allergen classification test (also can find out the specific foods that cause allergies). Allergen testing
Allergen detection
The occurrence and development of many clinical skin diseases are related to exposure to allergens. Most patients with allergic diseases are usually treated for symptom relief without finding the real cause of the allergy, and therefore cannot do targeted prevention and treatment, resulting in repeated aggravation of the condition and prolongation.
Therefore, it is recommended that patients with frequent allergies must undergo allergen screening tests to find out whether contact, ingestion or inhalation allergens are causing the allergic reactions in order to solve the problem at the root. Never treat allergies as a minor problem and ignore the examination and treatment, which eventually leads to serious consequences. Lin Chunling, Department of Dermatology, Affiliated Hospital of Armed Police Logistics College
Enzyme immunoassay is used to detect allergens quickly, accurately and painlessly. The method allows qualitative and quantitative detection of allergens (total IgE, total IgG, specific IgE, etc.) in the patient’s serum or plasma. IVT is used to detect IgE-mediated tachyphylaxis, which has a significant seasonality, short onset and high incidence.
The test solves the difficulty that conventional skin tests are not suitable for detecting allergens in patients with type I allergic reactions during the attack period. FIgG is used to detect delayed allergic reactions. The reaction is mainly food-related, i.e. food intolerance. It manifests itself as a few days or a week after exposure to the allergen before the onset of the associated symptoms. These allergic reactions are often misdiagnosed due to a lag in symptoms and manifest clinically as chronic symptoms in various systems. If the cause is unknown for a long period of time, recurrent and untreated, it is recommended that food IgG should be checked.
Allergen screening test for people: patients with unknown causes of allergies, eczema, urticaria, allergic rhinitis, asthma, psoriasis and other patients should do a little allergen testing, which can be of great help in the prevention and treatment of diseases.
Allergen testing kits currently used by various hospitals can be broadly divided into these: 1, inhalant allergen screening test; 2, inhalant allergen screening test; 3, inhalant allergen classification test (this kit can find out the specific inhalant substances that cause allergic reactions such as dust mites, pollen, etc.); 4, inhalant allergen classification test (also can find out the specific foods that cause allergies). Allergen testing.
Myths of allergen testing
Allergen blood tests generally require the separation of serum from red blood cells and the use of serum plus allergen sample reagents to detect the final results. This is because the serum is not separated from the red blood cells and the allergy reagents are used directly to reduce the cost of operation, which affects the accuracy of the final test.
Various methods of allergen testing puncture test for allergens
The prick test can be considered as a special intradermal test, which is currently an internationally respected method for in vivo detection of allergens, especially in Europe and the United States. Because it is the skin of the puncture fluid is only one ten thousandth of the intradermal test, safety and high sensitivity, high accuracy, due to small skin lesions, patients without pain, such as by mosquito bites and other characteristics, has gradually replaced the traditional intradermal test.
Principle.
When a certain allergen enters the skin, patients who have a rapid allergic reaction to certain substances immediately and specifically cause the mast cells in the skin to degranulate and release histamine and other active substances, resulting in local capillary dilation (erythema) and increased capillary permeability (edema, wind mass), and those who are positive indicate allergy to the antigen.
Operation method.
First put a drop of puncture skin test solution on the skin, then use a puncture needle to pass through the drop and gently pierce into the skin.
Patch test
The patch test has been used for a hundred years and has proven its reliability for the diagnosis of contact dermatitis and certain allergic skin diseases, promoting the development of contact dermatitis and skin allergy detection. Our hospital uses European standardized testing reagents for accurate testing.
Principle.
The suspected allergenic substance is applied to the patient’s skin, and the antigen is presented to T lymphocytes by antigen presenting cells after entering the organism through the skin or mucous membrane, which activates specific T lymphocytes and induces an inflammatory response.
Indications.
1, Contact dermatitis, eczema, occupational dermatosis and other skin diseases that occur as a result of metamorphic reactions caused by exposure to certain substances.
2, When the cause is unknown or there are several substances in contact and the cause needs to be found, patch test can be done.
Specific method.
The reagent is applied to the skin and observed for a period of time, and the skin reaction to the contact is judged according to whether it is allergic to the substance.
Test types.
1, nickel sulfate: a variety of metals and gold-plated items;
2, lanolin alcohol: a variety of ointments, creams, skin care products and soaps;
3.Neomycin sulfate: topical antibiotic creams, skin lotions, ointments, eye drops and ear drops;
4, potassium dichromate: cement and a variety of chemical products;
5, cocaine mixture: a variety of local anesthetics;
6, spice mixtures: cosmetics, spices and seasonings;
7, rosin: adhesives, sealants;
8, epoxy resin: adhesives, surface coatings and paints;
9, quinoline mixture: certain drugs such as cold cream, ointment, ointment and bandages;
10, Peruvian balsam: a variety of beauty agents, perfumes and cough syrup, cough sugar, chewing gum and candy snacks;
11, ethylenediamine dihydrochloride: stabilizers, emulsifiers and local antiseptics / antibiotic cream / eye drops and nose drops;
12, chloride: gold-plated items and artificial jewelry;
13, tert-butanol formaldehyde resin: leather products, furniture and shoe industry waterproof glue;
14, aromatic mixtures: beauty agents, dermatological topical creams and bandages;
15, Kappa mixture: rubber products, insecticides and some glues;
16, carbon black rubber mixture: tires, handles and water pipes;
17, CL + ME isothiazolinone: a variety of shampoos, creams, skin lotions and other skin care products;
18, quart-15: creams, skin care solutions, shampoos, soaps and actually beauty agents and skin care products;
19, mercaptobenzothiazole: a variety of rubber products, adhesives and industrial preservatives;
20, p-phenylenediamine: permanent and non-permanent hair coloring agents;
21, formaldehyde: a variety of construction materials and plastic industry;
22, mercaptan mixture: a variety of rubber products, such as shoes, gloves and rubber bands;
23, thimerosal: some beauty agents, nose drops and ear drops;
24.Thiuranum mixture: almost all rubber products.
Total IgE test
Total IgE test is a test to determine the body’s allergic constitution, which is an important sign of allergy. When it is increased and there is no parasitic infection, it indicates that the patient is in an allergic state.
Food intolerance
Many chronic diseases have been clinically proven to be food-related, and the symptoms disappear after the problematic food is removed, which is called food intolerance. Food intolerance testing is also the only late-response (IgG) test for food allergies. Chronic symptoms such as diarrhea, mouth ulcers, hives, acne, migraines, easy fatigue, depression, asthma, sleep disorders, and teeth grinding, all of which cannot be identified as the cause, should be tested for food intolerance and may be related to food intolerance.
Food intolerance
Many chronic diseases have been clinically proven to be food-related, and the symptoms disappear after the problematic food is removed, which is called food intolerance. Food intolerance testing is also the only late-response (IgG) test for food allergies. Chronic symptoms such as diarrhea, mouth ulcers, hives, acne, migraines, easy fatigue, depression, asthma, sleep disorders, and teeth grinding should be tested for food intolerance if no cause can be identified, all of which may be related to food intolerance.