There are differences between self-financed drugs and free drugs in terms of mode of administration, price, efficacy and adverse effects. 1. The way of taking: AIDS free drugs usually need to take a variety of preparations, while many of the self-financed drugs for a single tablet preparation, more convenient to take. 2. Price: the price of self-financed drugs is relatively high, basically in the thousands of dollars a month, while the free drugs do not require additional expenditure. 3. Efficacy: both free drugs and self-financed drugs can achieve good efficacy and control viral replication after regular use; however, self-financed drugs have more varieties and a higher barrier to drug resistance. 4. Free drugs also have relatively more adverse reactions, such as gastrointestinal reactions, liver and kidney function damage, etc.; self-financed drugs usually have fewer adverse reactions and better compliance with long-term medication. Drugs should be used under the guidance of a professional physician, and should not be used arbitrarily by oneself.