Topical treatment drugs for premature ejaculation mainly include testosterone patches, prostaglandin E1 cream, etc., but the specific efficacy varies from person to person, and it may not necessarily be able to achieve a radical cure. 1. Testosterone patch: It is suitable for those who suffer from premature ejaculation due to hypogonadism and low level of sex hormones. However, this drug is contraindicated in people who are allergic to it, people with confirmed or suspected prostate cancer, and there may also be local skin irritation symptoms, acne and other adverse reactions during the use of the drug. 2. Prostaglandin E1 cream: it is suitable for those who have premature ejaculation caused by erectile dysfunction. However, this drug is prohibited for those who are allergic to prostaglandin E1 or those who have glans, urethritis, thrombocytosis, venous thrombosis tendency, etc. Adverse reactions include localized redness, swelling, glans and urethral pain, and so on. However, it should be noted that the specific efficacy of the use of the above drugs can be due to the use of medication, the cause of the disease, the severity of the disease and other factors, there are individual differences, therefore, it can not be asserted that the use of a certain drug will be able to completely cure premature ejaculation. In addition, it should be noted that, compared with the above-mentioned external therapeutic drugs, the clinical treatment of premature ejaculation is more often used in oral form (such as dapoxetine and other 5-hydroxytryptamine reuptake inhibitors) and injectable (such as lidocaine and other local anesthetics) drugs. In addition to medication, psychotherapy (e.g. cognitive behavioral therapy) and surgery (e.g. dorsal penile nerve selective dissection) are also the main measures for the treatment of premature ejaculation. Do not dispose of yourself and blindly use drugs to avoid adverse consequences.