Hepatitis B major triple positive to minor triple positive, that is, hepatitis B e antigen turn negative, e antibody appear positive. The big triple positive is the body carries hepatitis B virus, and the virus is more contagious, just reflecting the body infected with hepatitis B virus presents a kind of immune state, and the severity of the disease is not related to the hepatitis active stage of the big triple positive patients need to be given treatment, due to the quantitative viral DNA and aminotransferase will appear obvious elevation, give entecavir, adefovir and other antiviral drugs. Hepatitis B Minor Triple Positive, is defined as the results of the Hepatitis B Penta test showing positive results for Hepatitis B Surface Antigen, Hepatitis B e Antibody and Hepatitis B Core Antibody, while the remaining two are negative. Many Hepatitis B Minor Triple Positive are converted from Major Triple Positive, which usually indicates weakened viral replication and reduced infectiousness. Patients need to be tested for liver function, hepatitis B virus DNA load, and liver ultrasound. If hepatitis B virus infection is diagnosed, early and standardized treatment is recommended to minimize the adverse effects of the disease.