Premature ejaculation treatment drugs are antidepressants, 5-hydroxytryptamine reuptake inhibitors, local epidermal anesthetic and so on. 1. Antidepressants: such as chlorpromazine, venlafaxine, can block the central nervous system to norepinephrine and 5-hydroxytryptamine reuptake function, play the role of antidepressant, sedative, anticholinergic. Some patients may experience adverse reactions such as excessive sweating, dry mouth, blurred vision, and difficulty in urination after using such drugs. This drug is contraindicated in patients with severe heart disease, history of myocardial infarction, epilepsy, glaucoma, urinary retention, and allergy to tricyclic drugs. 2. 5-hydroxytryptamine reuptake inhibitors: such as paroxetine, sertraline, etc., through the inhibition of neurotransmitter reuptake, thus enhancing the effect of 5-hydroxytryptamine, can improve mood. After taking the drug, some patients may experience adverse reactions such as nausea, dry mouth, diarrhea, and loss of libido. Allergy to the drug is prohibited . 3. Local epidermal anesthetics: patients can also use topical lidocaine cream, dacronine cream and other local anesthetics to reduce the sensitivity of the head of the penis, control ejaculation. However, a large amount of medication may lead to adverse reactions such as the inability to erect the penis. It is prohibited for those who suffer from heart failure and are allergic to the drug. The above drugs need to be used in a standardized manner under the guidance of a doctor to avoid adverse consequences.