A mole on the shoulder, usually an epidermal nevus, usually does not need to be removed if it does not significantly affect aesthetics and does not have abnormal symptoms; whereas if the patient is self-conscious about the aesthetic impact or if it is in a friction area, it needs to be removed. Epidermal moles on the shoulder may be related to genetic factors, changes in hormone levels in the body, or environmental factors. If the nevus is relatively small, does not affect aesthetics, and has no discomfort symptoms, it usually does not require special treatment and does not need to be removed. However, if the epidermal nevus is relatively large and affects aesthetics, or if the epidermal nevus is located in the friction area of underwear, you can consider going to a regular hospital for laser treatment or surgical treatment to remove the nevus. If the area of epidermal nevus shows uncomfortable symptoms, such as epidermal nevus increasing in size in a short period of time, or accompanied by redness, swelling, pus, pain, itching and other symptoms, it is necessary to go to the regular hospital for consultation, and then follow the doctor’s instructions to adopt the appropriate treatment plan after a clear diagnosis. It is recommended that patients with moles on the shoulders go to regular hospitals for timely consultation and standardized treatment under the guidance of doctors.