Severe premature ejaculation may lead to infertility, and mild premature ejaculation usually does not lead to female infertility. For premature ejaculation caused by psychological factors, psychological adjustments should be made, and when organic lesions exist, medication should also be administered. When men have premature ejaculation, and premature ejaculation is more serious, for example, at the beginning of sexual life, the penis did not enter the female vagina before rapid ejaculation, may lead to female infertility, if it is a mild premature ejaculation, able to carry on sexual life, just a shorter time of sexual life, generally will not lead to female infertility. For psychological factors caused by premature ejaculation, the main psychological adjustment, reduce psychological pressure, and with the topical lidocaine gel. For premature ejaculation caused by glans phimosis, it can be treated with topical erythromycin ointment, gramicidin ointment and other drugs. If there is a long foreskin can consider circumcision. In the presence of prostatitis, the application of prostate Shutong capsule, amoxicillin and other medications. In the process of treatment, we should listen to the doctor’s guidance, safe and reasonable use of medication treatment, not indiscriminate use of drugs.