Sudden blisters on the hands are usually infected by external viruses or other substances and are medically known as blisters. Patients with itchy blisters on their hands should first consider whether they are caused by trauma, such as being burned, which may cause localized blistering and itching symptoms that can usually be relieved in the short term after disinfection and debridement. If a patient naturally develops blisters on the hands, it may be related to a skin disease of the palms and fingers, and the eradication method should be tailored to the patient’s specific situation due to individual differences: 1. Blistering Tinea Versicolor: A ringworm infection of the skin that occurs on the palms and fingers and can spread to the back of the hands and wrists, commonly manifesting as papules and blisters with significant itching. It can be treated with topical medications, such as ketoconazole ointment and miconazole nitrate cream. If it is a persistent fungal infection, you can also choose the appropriate oral medication for treatment, such as terbinafine, itraconazole, etc.; 2, sweat blister: blistering disease of the palm and fingers, usually manifested as epidermal oozing blisters resulting in lesions, the size of a grain of rice, surface elevation, accompanied by itching and burning sensation. Usually can be reduced or self-healing after middle age, can be treated with topical glyburide lotion, such as dry flakes peeling, but also can choose to use topical glucocorticoid ointment, salicylic acid ointment, urea cream, etc.; 3, papular urticaria: hands such as very itchy blisters, may be due to mosquito bites caused by skin allergies, namely papular urticaria. Usually you can apply topical anthropomorphic drugs, mometasone furoate cream, etc. If there is a breakout, you can also use topical erythromycin ointment, etc. In addition to topical medications, oral antihistamines, such as loratadine and cetirizine, usually need to be applied in combination to relieve allergic symptoms; 4. Corn rash: sweat pore occlusion leads to sweat retention in the skin, and the damage is mostly pinpoint to needle-sized transparent blisters, usually accompanied by itching and burning sensation. The rash initially appears as a small patchy rash, which quickly develops into a 2-4mm blister with thin walls and clarified contents, and can produce itching if it appears on the hands. It can be treated with topical antiviral creams, such as ribavirin and ganciclovir. Patients with blisters on the hands and a pronounced itching sensation can go to a hospital dermatology department for diagnosis and choose a suitable treatment according to their condition to be able to better achieve the effect of eradication.