Fishy grass injection is a pure Chinese medicine preparation widely used in China, and allergic reactions are rare. However, the drug can lead to severe reactions such as anaphylaxis, which should be highly valued by the clinic. Fishweed injection has the effect of clearing heat, detoxifying and inducing dampness, and in vitro antimicrobial experiments have proved that it has obvious inhibitory effect on pneumococcus, staphylococcus aureus, hemolytic streptococcus, cattacoccus, gonococcus, dysentery bacillus, metatyphoid bacillus and diphtheria bacillus, etc. It is commonly used in clinic for phlegm-heat cough, urinary tract infection, carbuncle boils and so on. In recent years, with the wide application of this drug and the continuous improvement of the adverse drug reaction monitoring system, the occurrence of allergic reactions has increased, and the number of cases of anaphylactic shock caused by this drug has also increased year by year. At present, the exact mechanism of allergic reaction is still unclear, the possible causes are: 1, individual differences in patients (such as hypersensitive body); 2, the complex composition of Chinese medicine preparation, which contains protein, starch, tannin, pigment, mucus, resin, volatile oils, etc.; 3, the extraction of the purity is not enough or difficult to purify, containing other allergenic impurities; 4, high-temperature heating, sterilization or storage process due to oxidation, polymerization, hydrolysis of allergenic substances. Sensitizer. 5, the number of particles after the infusion of changes in the number of matching. Systemic allergic reaction is a typical type I allergic reaction, characterized by rapid onset, with symptoms appearing in a few seconds to ten minutes. However, the drug specification does not explain in detail the severity of the allergic reaction to Cichlidium Fischeri Injection, and only briefly mentions that it is forbidden for allergic people; at the same time, the drug is a Chinese medicine preparation, which does not require allergy test and has no preparation method, so the danger of its clinical application is easily overlooked. We put forward the following precautions: 1. It is forbidden to bring this preparation for use outside the hospital, so as to avoid accidents due to the lack of necessary first aid measures after the occurrence of an allergic reaction; 2. Before using this product, the patient’s medical history should be inquired in detail, and allergic individuals should use it with caution; 3. During the period of medication, more observations should be made, especially in the first infusion of the first time for the first time for female patients aged 30 to 40 years old in the beginning of the 5-10min; 4. Prepare the rescue medicines and the first time A doctor should be present during the infusion to ensure the safety of patients.