Drug-induced gastrointestinal reactions can be treated symptomatically depending on the type of drug, such as nonsteroidal anti-inflammatory drugs, macrolides and bisphosphonates. 1. Non-steroidal anti-inflammatory drugs: such as ibuprofen, acetaminophen, loxoprofen, etc., are prone to nausea, abdominal discomfort, gastritis, small intestinal mucosal damage and other adverse reactions, and it is recommended that the dose be gradually increased, avoiding the use of drugs on an empty stomach. 2. Macrolides: such as erythromycin, azithromycin, clarithromycin, etc., prone to diarrhea, abdominal distension and other adverse reactions, can be taken half an hour before the medication montelukast, or when the medication at the same time to take vitamin B6, scopolamine, to avoid fasting with the drug. 3. Bisphosphonate drugs: such as alendronate, ibandronate, risedronate, etc., nausea, acid reflux, poor appetite and other symptoms are likely to occur, and the drug should be kept in an upright position within thirty minutes, avoiding high doses and fasting. The above drugs should be used under the guidance of professional physicians. If discomfort occurs after oral administration of the drugs, one should consult a doctor in time and intervene under the guidance of a professional physician.