Many newborn babies have symptoms such as vomiting, diarrhea, bloating, constipation, crying and so on, which make parents anxious, in fact, the baby has symptoms of indigestion, and need to promptly clarify the cause and take appropriate conditioning and treatment measures. Newborn babies are just born, due to the immature development and function of the organs, especially the immature development of the digestive tract, the function of the digestive system is not perfect, gastrointestinal peristaltic function and digestive tract coordination movement is poor, parents feeding experience and care is not enough, easy to appear indigestion, manifested as vomiting, bloating, diarrhea, crying and other symptoms. Too much milk, too much gas in the stomach, too low temperature of milk powder or improper configuration of milk powder ratio can easily lead to indigestion. Breastfeeding mothers should keep a happy mood, get enough rest, eat a light and nutritious diet, and avoid eating cold, greasy and spicy foods. Some breastfed babies continue to have similar indigestion symptoms, consider lactose intolerance, milk protein allergy. Lactose intolerance can lead to lactose malabsorption due to lactase deficiency or reduced activity. Undigested lactose entering the colon can be fermented by bacteria to produce short-chain fatty acids such as acetic acid and propionic acid and gases such as carbon dioxide, which in turn increases intestinal osmotic pressure, resulting in clinical manifestations such as intestinal tinnitus, abdominal pain, bloating and osmotic diarrhea. Breastfed babies can take lactase before breastfeeding, and formula-fed babies switch to special formula without lactose. If the baby has persistent diarrhea with blood in the stool and eczema, consider milk protein allergy and need to stop breast milk and switch to amino acid formula or deeply hydrolyzed formula. Newborns with indigestion symptoms that affect growth and development need to seek prompt medical attention to assess the cause and take appropriate treatment measures to ensure the healthy growth of the baby.