Moles on the face have various beautiful names, such as “beauty mole”, “lucky mole” and “hidden pearl in the eyebrow”. Whoever has such a mole on his face will inevitably be envied by many people, that represents good fortune, even if you are poor and suffering now, it will be considered that you will eventually come to the end of your misery. So we think that there is nothing wrong with moles, they are the knot of good fortune. However, we do not know that most moles are benign and do not harm our physical and mental health, but there are a few people who have moles that can become malignant. Moles, medically called pigmented moles, can appear on any part of the body, such as outside the body surface, nasal cavity, external ear canal, lid margin, tear mound, oral mucosa, and mucosal surface of the gastrointestinal tract. According to medical experts, every person has more than 20 moles on average, and 40% of benign moles occur on the head, face and neck. Pigmented moles growing on the palms of hands, feet, vulva, glans, back and face are very prone to malignant changes because they are often rubbed, and some people even suspect that they are detrimental to their appearance by artificially picking, pinching, scratching or picking with needles, freezing, etc. In medical literature and in our medical practice, we often see and hear that some patients undergo craniotomy for brain tumor, and after removing the tumor, it is found that it is not a primary brain tumor, but a metastatic mole that metastasized to the brain due to the malignant transformation of black pigmented nevus on the sole of the foot, etc. Metastatic nevus can cause hemiplegia, aphasia, squinting eyes, and even death. Beware of the malignant transformation of “beauty nevus”.