Severe premature ejaculation at the age of 33 with the possibility of cure. Premature ejaculation is a common symptom in urology, belonging to the ejaculation dysfunction. Generally speaking, ejaculation within a short period of time after re-entering the woman’s vagina, and the man is unable to control the time of ejaculation, can be regarded as premature ejaculation. If ejaculation occurs with slight stimulation, it can be regarded as severe premature ejaculation, which can still be cured after active treatment. Patients need to adjust their mindset, avoid excessive tension and low self-esteem, with oral sertraline hydrochloride, dapoxetine hydrochloride and other drugs, can also be applied on the glans penis lidocaine gel to reduce sensitivity, prolong the ejaculation time. If the effect of drug treatment is not good, it can also be treated by dorsal penile neurotomy, which can improve the symptoms. In summary, severe premature ejaculation can still be cured, but the patient should actively go to the regular hospital, strictly comply with the doctor’s instructions for treatment, not indiscriminate use of drugs, so as not to aggravate the condition.