Limb ulcers are an important complication of systemic scleroderma, and persistent and recurrent ulcers can cause severe pain, infection, gangrene, functional impairment, and decreased quality of life, causing great suffering to patients. Because of this, the study of scleroderma extremity ulcers has become a hot issue for research in recent years. I. Population prevention High-risk groups are those who are in contact with coal mines, metal mines, silica mines, chemical workers, etc. The awareness of protection of such personnel should be strengthened, labor protection should be done, and regular check-ups should be conducted. Personal prevention (1) Primary prevention: Nowadays, most people believe that this disease is probably an autoimmune disease caused by genetic factors, plus persistent chronic infection. Some cases often overlap with systemic lupus erythematosus, Hashimoto’s thyroiditis, rheumatoid arthritis, and Schellen’s syndrome, etc. Therefore, prevention should be paid more attention to the above risk factors. ①Remove infected lesions, pay attention to hygiene, strengthen physical exercise, and improve your immune function. ②Living a regular life, combining work and rest, relaxing mood, avoiding strong mental stimulation. ③Strengthen nutrition, forbid eating raw and cold food, and pay attention to warm tonic. (2) Secondary prevention: Early diagnosis: diagnosis can be made based on typical skin sclerosis and systemic damage. (3) Tertiary prevention: ①Progressive systemic scleroderma progresses slowly, some have the tendency to remit on their own, do not easily stop or give up treatment. (2) Pay attention to physical exercise, reasonable life pattern, avoid emotional stimulation and changes. ③There is no special medicine for this disease, and throughout the course of the disease, it is important to actively cooperate with Chinese medicine therapy for the control of the disease. ④Patients with Raynaud’s phenomenon should pay attention to heat preservation and avoid cold stimulation. ⑤Smoking is prohibited.