Omicron is a variant of the novel coronavirus. The Omicron variant is spreading rapidly internationally, and compared to other variant strains, the Omicron strain is insidious and more transmissible, with relatively mild symptoms and fewer severe illnesses in infected patients. The main symptoms are fever, dry cough, sore throat, headache, malaise and nasal congestion. The specific manifestations are: 1, the upper respiratory tract symptoms are heavier, with more cough and sore throat; 2, some patients have fever symptoms, mainly moderate fever, more around 38.5℃; 3, the gastrointestinal symptoms are relatively few, and in the past, the gastrointestinal symptoms (nausea, vomiting, diarrhea) are relatively more. In addition, relevant studies have shown that omicron is more likely to infect the upper respiratory tract of humans, and its replication rate in human bronchial tubes is 70 times faster than that of the delta mutant strain, while in human lung tissue it is 10 times slower than that of the delta mutant strain. Therefore, the initial symptoms of infection with omicron are very much like the common cold, and special attention should be paid to the following 8 symptoms if they appear, and promptly go to the hospital for screening. 1. sore throat, throat 2. nasal congestion and runny nose; 3. sneezing; 4. headache; 5. muscle aches; 6. back pain; 7. night sweats; 8. fatigue and loss of appetite. In conclusion, for Omicron variant, both prevention and control as well as treatment should not be taken lightly. Once symptoms of suspected Neocrown pneumonia appear, timely consultation should be made according to standardized procedures with good personal protection.