Skin whitening is the most requested and important skin care item for women, not only for healthy and beautiful white skin, but also to prevent excessive melanin deposition and UV damage that can lead to melanoma, pigmentation disorders, pigment spots, solar dermatitis, polymorphic sun rash, skin melanosis, and even cancerous skin diseases such as solar keratosis, basal cell carcinoma, SCC, etc. As our surrounding environment continues to aggravated pollution, the intake of additives such as pesticides toxins hormones in food, everyone’s work and study stress increase, mental endocrine disorders immune deficiency, unreasonable and irregular use of cosmetics and many other problems, facial skin melanin deposition has become the most concerned about women’s beauty topics, but also dermatologists to face a major medical treatment cosmetic problems, to guide the correct and reasonable treatment of melanin and application of whitening agents daily care to avoid aggravation of skin disease and aggravation of pigmentation. In clinical practice, we commonly see the following different degrees of skin damage and increased melanin deposition problems: 1, the use of rapid whitening agents: the short-term effect is better, with the accumulation of toxic substances, there is irreversible melanin deposition, and even skin melanosis, heavy metal poisoning and other serious clinical diseases. 2, the use of whitening cosmetics with added hormones: will also have a certain whitening effect, once you stop using, a variety of skin problems, long-term use, the formation of hormone-dependent dermatitis, resulting in facial skin atrophy thinning, pigmentation spots, hirsutism, easy sensitivity, inflammation, redness, itching, dry flaking, acne formation, capillary dilation, accelerated wrinkle generation and other serious skin diseases. 3, neglect of skin protection and care: many women, because of busy work or other reasons, neglect or simplify the skin care process and develop sunlight UV skin damage (increased melanin in exposed areas of the skin, darkening of skin tone, appearance and aggravation of pigmentation, redness, itching, dryness, pain, flaking, keratinization) and other skin problems. 4.Primary pigmentation diseases of the face, irregular and unreasonable treatment, aggravating the primary disease and increasing melanin. 5, facial skin diseases left pigmentation spots: eczema, allergic dermatitis, cosmetic dermatitis, acne, solar dermatitis, skin infections and other skin diseases, there will be different degrees of pigmentation after the improvement or cure, especially inflammatory skin diseases, the chance of pigmentation is greater, also includes pigmentation spots after trauma burn burns.