The treatment of flat warts includes local medication, drug injection, oral medication, surgical treatment, and physical therapy. 1. topical medication: salicylic acid can play a therapeutic role by promoting epidermal exfoliation, retinoic acid cream plays a role through the regulation of cellular immunity and the regulation of epithelial cell proliferation, imiquimod ointment can activate the immune cells to stimulate the body to recognize the virus, interferon α-2b cream has the effect of inhibiting viral replication and enhancing cellular immunity. 2. Drug injection: vitamin D3 intradermal injection is effective for multiple lesions, bleomycin intradermal injection can make the lesion tissue necrosis to form a black crust and gradually fall off after a few weeks. 3. Oral medication: there is no accurate and effective anti-HPV medication, but immunomodulators such as interferon and levamisole are often used in clinical practice to complement the treatment. 4. Surgery: Surgery can be performed to directly remove the skin lesions. 5. physical therapy: commonly used CO2 laser, liquid nitrogen freezing, microwave therapy and other physical therapy treatment means.