Botulinum toxin is the common name for “botulinum toxin”, a toxic protein secreted by Clostridium botulinum during the reproduction process, which is highly neurotoxic. It acts on the endings of cholinergic motor nerves, interfering with the release of acetylcholine from motor nerve endings, blocking the transmission of information between nerves and muscles, thus causing flaccid paralysis of muscles and preventing muscle fibers from contracting. In plastic and cosmetic surgery, Botox is mainly used for the treatment of facial wrinkle reduction. Compared to other wrinkle removal products, its action and safety are irreplaceable, and it is currently the best method for removing power wrinkles. In addition, it can be used for the treatment of muscle hypertrophy, axillary odor, and hyperhidrosis. The procedure of Botox injection for wrinkle removal is very simple, the doctor first disinfects the candidate’s face hole, then determines the location of the wrinkle to determine the injection site, followed by injection in order and dosage, and finally disinfection with alcohol wipe. Do not take aspirin as well as aminoglycoside antibiotic drugs (such as gentamicin, kanamycin, etc.) for 2 weeks prior to the injection. After the injection, sit quietly and rest, observe for 10-15 minutes, and leave after there are no uncomfortable symptoms. Be careful not to massage, apply heat or rub the injection site to avoid the spread of Botulinum toxin type A to other muscles. After the injection, there will be local bleeding, swelling, and petechiae. Patients with bite muscle injections will experience chewing weakness and soreness in the early stage, but they will all disappear soon. Patients who have wrinkle reduction injections usually take effect after 2-3 days, while patients who have bite muscle injections usually start to show results after 2 weeks, and the effect is obvious after 1 month. The advantages of botulinum toxin wrinkle removal are small damage, fast results, easy operation, and no interference with work. The limitations of Botox wrinkle removal: 1. Injecting one shot of Botox, the maintenance of wrinkle removal effect is usually around 4 months to 6 months, to be effective for a long time, it needs to be repeatedly injected several times. 2. Using Botox to remove wrinkles is only suitable for power wrinkles, for those wrinkles that exist even when there is no expression movement, or those wrinkles due to skin relaxation, the effect is not good. As for its toxic side effects, they basically do not occur as long as the injection is done in strict accordance with the safe dose. Sometimes, because of the distribution of the drug or too much injection, it can have some effects on facial muscle activity, such as muscles appearing somewhat stiff, drooping of the corners of the mouth, ptosis or even diplopia. However, these adverse reactions will return to natural after a maximum of a few months when the drug loses its effect, and everything will return without leaving after-effects. However, Botox is, after all, a neurotoxin, and although it is used in very small and safe doses as a wrinkle remover, its toxicity and side effects are, after all, objective. Due to the toxicity and side effects of botulinum toxin, some people may occasionally experience fever, weakness and poor appetite after the injection, mostly due to allergy, which can disappear on its own within a few weeks. Severe anaphylaxis, although extremely low in incidence, is quite dangerous, so Botox must be strictly limited to medical settings. Improper injections may cause swallowing, breathing difficulties, and even life-threatening conditions. People who cannot receive Botox injection treatment: 1, pregnant and lactating women; 2, patients with thymus disease, neuromuscular system disease, ptosis; 3, people who are very thin and have heart, liver, kidney and other internal diseases; 4, allergic people, especially those who are allergic to the toxin and the ingredients in the preparation; 5, patients who are taking quinine, aminoglycosides or calcium channel blockers.