Due to the reason of human race, the breast development of Chinese women is far different from that of foreign women, which makes a lot of women who love to be beautiful worry a lot. Most Chinese women have poor breast development in adulthood, some even have no development, flat chest, lack of women’s kind of full breasts, high breasts and show the curve of beauty, thus in work, study and life lack of self-confidence. Female breast is one of the significant symbols of female physical beauty, full and elastic breasts are the characteristics of female charm, the pursuit of breast beauty is human nature, is a manifestation of human consciousness and social progress. Therefore, the majority of women are determined to regain self-confidence, “breasts”, which gorgeous words and phrases in the advertisements have a wide range of markets. How many women have been attracted by “no surgery, no bleeding, no hospitalization, no scarring, rapid breast enlargement”? They are eager to have a pair of full, firm, sexy and charming breasts, and thus step into the dreadful abyss regardless of the consequences. Is polyacrylamide hydrogel injection safe for breast augmentation? The answer is yes. Polyacrylamide hydrogel injections for breast augmentation have brought endless troubles to women. Why is this so? To answer this question, we must know the following two aspects of the problem: 1, what kind of biomaterial substitutes can be used in clinical practice? 2. What kind of breast augmentation method is “polyacrylamide hydrogel injection”? As a kind of biomaterial substitute, it must have excellent compatibility with human body in biology, non-toxic, non-teratogenic and foreign body reaction; it must have certain strength in biomechanics; it must have stable chemical performance in chemistry, and it will not have toxicity due to chemical change after being put into human body for a long period of time; the most important and basic one is that as a kind of excellent biomaterial substitute, it must be able to be taken out completely once there is any problem after being put into human body. Once there is a problem, it must be taken out completely, otherwise it can not be used in the clinic. We know that “polyacrylamide hydrogel” is a kind of biological material substitute, it is mixed with water and injected into human breast in gel state, once there are uncomfortable symptoms, it is very difficult to take it out completely, and the residual “polyacrylamide hydrogel” will cause endless harm to human body. The residual “polyacrylamide hydrogel” will cause endless harm to human body, so it is not a good material for breast augmentation from the point of view of biomaterials. Polyacrylamide hydrogel injection for breast augmentation is to inject “polyacrylamide hydrogel”, which is commonly known as “artificial fat”, into breasts through a breast augmentation injection needle, so that the breasts will be rapidly augmented to achieve the purpose of breast augmentation. “No surgery, no bleeding, no hospitalization, no scarring, rapid breast augmentation”. However, a powerful “bomb” that does not know when it will explode has been placed in human breasts, that is, a lot of women who have breast augmentation injections complain of continuous pain at the injection site, hard knots of different sizes when touching the breasts, and some of them even have ulceration and secretion of pus at the injection site, which brings harm and endless suffering to the patient’s body and psychology. This brings harm and endless troubles to the patient’s body and psychology. We have received many women with polyacrylamide hydrogel injection for breast augmentation in outpatient clinic, and they are now in great pain and regret. A 40-year-old woman from Kunming, Yunnan Province suffered from pain at the injection site after breast augmentation, which brought pain to her life and work. She sought medical treatment and limped all over the country. When she realized that no matter how hard we tried, it was impossible to remove the injected polyacrylamide hydrogel completely by surgery, she was in so much pain that she wanted to have her breasts removed. What a vicious stimulus this creates for the patient! How sad is this outcome that will affect the patient for the rest of her life! There is also a young girl in her twenties from Tangshan, who originally thought that she could improve her self-confidence through polyacrylamide hydrogel breast augmentation, which would bring her a better future, but she did not expect that soon after the polyacrylamide hydrogel breast augmentation injection, the left inner side of her breast broke down, and secretions continued to flow out, and despite our surgical efforts, the broken down place still could not be healed, and she is still under treatment. The patient is still under treatment. This end not only brings great inconvenience to the patient’s life, but also brings a blow to the ideal of the girl. We also know: polyacrylamide hydrogel by acrylamide polymerization from a polymer, although non-toxic, but its predecessor “acrylamide” is a monomer, various literature reports that acrylamide is poisonous, can produce nephrotoxicity, the human body harm endless. Polyacrylamide hydrogel in the human body environment, how to change? When is it hydrolyzed? Is decomposed into acrylamide? The current study is not perfect, to be further explored. Therefore, polyacrylamide hydrogel is not suitable to be used as a substitute for biomaterials, nor is it suitable to be used for human breast augmentation. Ladies who love beauty, stay away from polyacrylamide hydrogel, don’t be confused by the flashy advertisements and don’t bring yourself lifelong pain by the false words.