Doxycycline Hydrochloride Tablets can treat acne and are commonly used as adjunctive therapy for patients with moderate to severe acne. Doxycycline Hydrochloride Tablets is a broad-spectrum bacteriostatic agent, with bactericidal effect at high concentration, which is commonly used in the clinic for diseases caused by infections of Gram-positive bacteria, Actinobacillus spp, Bacillus anthracis, Listeria monocytogenes, Clostridium difficile, and other causative organisms. Acne is mostly infected with Propionibacterium acnes, mild acne is often treated with topical medication, and moderate to severe acne can be treated with oral doxycycline hydrochloride. Doxycycline hydrochloride tablets for moderate to severe acne treatment, if the medication is not appropriate, can produce nausea, vomiting, abdominal pain, diarrhea, maculopapular rash, erythema headache, vomiting and other adverse reactions, it is recommended that the patient use the medication, strictly under the guidance of a professional physician to rationalize the use of medication, and should not blindly self-medication. It is generally contraindicated for those with a history of allergy to tetracyclines.