Leg blood vessel blockage needs to be treated according to the cause of the disease, generally there are anticoagulant, antiplatelet, antitumor and other drug therapy and surgical treatment and other methods. 1. Venous thrombosis: Since lower extremity venous thrombosis is easy to fall off and cause pulmonary embolism and other diseases, treatment should be active oral warfarin or injection of low molecular heparin and other anticoagulant drugs, and take surgical treatment if necessary. 2. Arterial embolism: when the degree of arterial blockage is mild, the main treatment is medication, including antiplatelet drugs such as aspirin and lipid-lowering drugs such as Rosuvastatin, etc.; when the degree of blockage is severe, surgical treatment is needed, such as arterial bypass grafting and stent implantation. 3. Arterial and venous blockage caused by other diseases: if the tumor of the lower limb grows large and presses the surrounding blood vessels, which leads to vascular blockage, then it needs to be treated according to the nature of the tumor. Generally, benign tumors are mainly treated by surgery, and malignant tumors need to be treated with comprehensive treatment such as surgery, chemotherapy, radiotherapy, and targeting. Leg blood vessel blockage should consult doctor in time, clarify the cause of disease, and treat under doctor’s guidance. The above drugs should be used under the guidance of a doctor, avoid self-medication.