Common drugs of anti-rheumatic drugs include methotrexate, leflunomide, salazosulfapyridine, etc. The side effects of different drugs are different, e.g. methotrexate can show liver damage, abnormal bone marrow suppression, etc.; leflunomide can show electrolyte disorders, itchy skin, etc.; and salazosulfapyridine can show perianal discomfort, palpitations, etc. Methotrexate is the drug of choice for rheumatic diseases, and the side effects may manifest as liver damage, gastrointestinal reactions, allergic reactions, blurred vision, chills and fever, bone marrow hematopoietic suppression, and lymphoproliferative disorders. Leflunomide is an immunosuppressant, and its side effects can manifest as electrolyte disorders, dizziness, pancytopenia, severe infections, and itchy skin. Liuzosulfapyridine has anti-inflammatory and immunomodulatory effects, and its adverse effects may include perianal discomfort, itchy skin, diarrhea and abdominal pain, dizziness, dyspnea, palpitations (rapid heartbeat, often accompanied by panic), and leukopenia. Rheumatic system diseases with a variety of drugs, and the side effects of each drug performance is not the same, should be standardized under the guidance of the doctor to use medication, the use of medication during the emergence of maladaptation timely medical treatment, so as not to aggravate the condition.