HPV type 53, although it is a high-risk HPV type, is not the more common HPV type in the development of cervical cancer and precancerous lesions and does not necessarily cause cancer. There are more than 160 known HPV types, among which 13-15 are closely related to the development of cervical intraepithelial lesions and cervical cancer, the most common being HPV 16 and 18, while HPV 53 is not one of them. Most HPV-DNA in immunocompetent women can turn negative after 10-24 months. Only 10% of immunocompromised or abnormal women with HPV infection will persist, but only a small percentage of persistent HPV infection may cause cervical lesions or cervical cancer. From persistent HPV infection to cervical precancerous lesions and finally to cervical cancer, it takes a certain amount of time, but how long it takes varies from person to person, in short, it is not certain that HPV infection will cause cancer. Therefore, when patients are found to be positive for HPV type 53 and cytology does not suggest abnormalities, regular follow-up is sufficient. In addition, women can effectively prevent HPV infection by vaccination, and different doses of vaccine are available for women at different times.