Bactrim cream is an antibiotic cream that can treat skin diseases such as folliculitis, boils and carbuncles caused by Staphylococcus aureus, or Streptococcus epidermidis infections, so Bactrim can treat fire boils. However, depending on the severity of the condition, the use of Bactrim alone may not necessarily cure the fire boils. You can take appropriate antibiotics such as roxithromycin, amoxicillin, cefixime tablets, etc. But the specific diagnosis and application of a certain drug treatment is recommended to be given under the guidance of a clinician for reasonable application to avoid delaying the condition.