Neonatal sepsis is an infectious disease with a high mortality rate caused by pathogens that invade the bloodstream and infect newborns during the neonatal period. Generally, there are no special clinical manifestations, which can easily cause misdiagnosis and lead to serious consequences or even death. 1, generally due to low intrinsic immunity plus pathogenic bacteria invasion caused. Newborns have poor immunity and are highly susceptible to infections. Common pathogens are bacteria, or other pathogens. The germs invade the blood circulation of the newborn and multiply in it, thus causing infection. 2. Clinically, they show non-specific symptoms such as less food, less crying, general depression and mental weakness, or symptoms such as hepatosplenomegaly, hemorrhage and shock manifestations. Only one or two symptoms should be taken seriously when there is a possibility of having sepsis. In particular, jaundice, especially if it is recurrent or sharply aggravated, there is a high chance of having sepsis. 3, sepsis treatment is generally based on the use of anti-infective drugs, but can also be used at the same time supportive therapy and immunotherapy. Also need to pay attention to the timely treatment of shock, protection of liver and kidney function. When parents find symptoms of sepsis, it is recommended to go to the hospital in time to confirm whether there is sepsis. In addition, parents also usually need to do a good job of preventing and treating infections in newborns.