Tadalafil does not cure premature ejaculation, it cures erectile dysfunction. Premature ejaculation requires the use of drugs such as dapoxetine, fluoxetine, and lidocaine as prescribed by the doctor. Tadalafil belongs to the selective and reversible inhibitor of cyclic guanosine monophosphate PDE5, which is mainly used for the treatment of erectile dysfunction in the clinic, so tadalafil can’t treat premature ejaculation. For patients with premature ejaculation, selective 5-hydroxytryptamine reuptake inhibitors, such as dapoxetine, need to be used under the guidance of a doctor, which can prolong ejaculation to a certain extent. In addition, if the patient with premature ejaculation has symptoms related to depressive symptoms, he or she needs to use antidepressants such as fluoxetine, sertraline, paroxetine, etc. as prescribed by the doctor. Secondly, patients can also follow the doctor’s instructions to use topical anesthetics such as lidocaine-proparacaine cream to reduce the sensitivity of the penis head. In summary, patients with premature ejaculation need to go to the hospital, strictly comply with the doctor’s prescription medication, do not use tadalafil on their own.