Glutamyltransferase is an important transferase enzyme in human serum and is abundant in the kidney, liver, pancreas, skeletal muscle, and heart muscle. There are many clinical conditions that can lead to high glutamyl transferase, which may be related to patients’ poor living habits, such as prolonged late night, strenuous activity or overwork, poor diet, etc. Generally, the value is slightly transient high, and can gradually return to normal after improving poor living habits. In addition, some pathological causes can also lead to higher glutamyl transferase. When local tissues or organs have lesions, it may lead to obstruction of glutamyl transferase excretion, which will reverse the flow of blood and lead to higher values. The high glutamyltransferase alone is not specific and the cause cannot be clarified by this one indicator, clinicians often need to combine the patient’s medical history and other test results for a comprehensive assessment.1. Alcohol or drug intake: Long-term or heavy drinkers, long-term drug users, such as phenytoin sodium, antipyrine, etc., may cause liver metabolism problems, glutamyltransferase into the blood, at this time the blood test results Generally, after stopping drugs or alcohol, the value can gradually return to normal; 2, liver disease: patients with various acute and chronic hepatitis may have high glutamyl transferase, such as viral hepatitis, alcoholic hepatitis, drug-related hepatitis, chronic active hepatitis, etc. Patients with cirrhosis, fatty liver and liver cancer may also have elevated values due to the destruction of liver cells and the entry of glutamyl transferase into the blood. Generally, it needs to be combined with other laboratory tests and imaging examinations to make a clear diagnosis, and if it is determined to be liver disease, liver-protective treatment needs to be actively given to control disease progression; 3. Biliary tract diseases: common clinical biliary tract diseases can also show symptoms of high glutamyl transferase, including biliary tract obstructive diseases, such as chronic cholestasis, sclerosing cholangitis, acute phase of cholelithiasis, or inflammation, such as cholecystitis, Cholangitis, etc., the bile duct obstruction, resulting in a large amount of glutamyl transferase accumulation into the blood, the laboratory results will indicate elevated glutamyl transferase. At this time to actively treat the original disease, lift the obstruction, glutamyl transferase can gradually return to normal; 4, heart disease: when acute myocardial infarction, congestive heart failure, myocarditis, myocardial cells are destroyed, which glutamyl transferase release, the patient’s laboratory tests will often appear glutamyl transferase elevation. In this case, bed rest is needed to avoid stimulation, electrocardiogram is performed, and then the cause of the disease is actively sought and targeted treatment is given.