Poor ovarian response (POR) is a pathological condition in which the ovaries do not respond well to gonadotropin (Gn) stimulation and is characterized by low follicle development, low peak blood estrogen, high Gn dosage, high cycle cancellation rate, low egg production and low clinical pregnancy rate. POR is diagnosed when 2 of the following 3 criteria are met: (i) advanced age (≥40 years) or other risk factors for poor ovarian response; (ii) low ovarian response in the previous IVF cycle with ≤3 eggs on the conventional regimen; (iii) decreased ovarian reserve [sinus follicle count (AFC) <5-7 or anti-mullerian hormone (amh) <0.5-1.1 μg/L]. The cause of POR is still not well understood, and its pathogenesis may be related to older age of the patient, chromosomal and genetic abnormalities, immune abnormalities such as anti-hyaline antibodies, obesity, and damage by adverse environmental factors. For ovarian hyporesponsiveness, we can use the traditional GnRH-a long regimen, GnRH-a short regimen and GnRH-A regimen (antagonist) for ovulation promotion during IVF, as well as non-traditional regimens such as microstimulation and natural cycles. In addition, the combination or pretreatment of growth hormone (GH), androgens (DHEA, testosterone), letrozole, estrogen, oral contraceptives (OC) and Chinese herbal medicine is also beneficial to improve the treatment outcome of POR patients.