The etiology of functional abdominal pain syndrome is diverse and rarely the same from patient to patient. The onset of functional abdominal pain syndrome is mostly due to different causes of brain-gastrointestinal axis dysfunction, which results in abdominal pain. Early adverse life events and psychosocial stress also tend to lead to the production of pain. Genetic factors, organismal sensitivities, and especially stressful events can trigger functional abdominal pain syndrome. Patients may have a history of abdominal surgery, panic, trauma, and dysmenorrhea. Abdominal pain is caused by peripheral nerve injury or abnormal regulation of pain by the central nervous system, commonly associated with abdominal surgery or pelvic nerve injury during pregnancy and delivery. In addition, increased visceral sensitivity is one of the important pathophysiologic changes in functional gastrointestinal disorders.