Chest tightness, shortness of breath, dyspnea, panic, tingling in the hands and feet may be caused by angina pectoris, myocardial infarction, aortic coarctation, chronic obstructive pulmonary disease, asthma, cervical spondylosis and other diseases. 1. Angina pectoris: a circulatory disease in which the coronary arteries become diseased due to various causes, resulting in myocardial ischemia. Symptoms such as chest tightness and shortness of breath, panic and chest pain can occur under exertion or rest. 2. Myocardial infarction: Myocardial necrosis due to ischemia caused by sudden obstruction of coronary artery. It is often characterized by sudden onset of crushing pain in the chest, chest tightness and shortness of breath, palpitations (rapid heartbeat, often accompanied by panic) and irritability. 3. Aortic coarctation: It is a life-threatening cardiovascular disease caused by the emergence of entrapment hematoma in the middle layer of the aorta. Clinical manifestations are more variable, the typical manifestation is severe pain in the chest, but also can have chest tightness and shortness of breath, panic, breathlessness, numbness of hands and feet and other symptoms. 4. Chronic Obstructive Pulmonary Disease (COPD): is a respiratory disease commonly found in middle-aged and elderly people, which often manifests itself as coughing, coughing up phlegm, dyspnea, chest tightness, shortness of breath and other symptoms. 5. Asthma: a chronic airway disease characterized by airway hyperresponsiveness and chronic inflammation, often caused by environmental factors, can have shortness of breath, chest tightness, cough, dyspnea and even cyanosis and other manifestations. 6. Cervical spondylosis: it is a degenerative disease of the cervical spine, often caused by overloaded use of the cervical spine or poor sitting posture, which can be accompanied by dizziness, vertigo, chest tightness and nausea, numbness or weakness of the hands and feet and other symptoms. If these symptoms occur and are not relieved or gradually worsened after resting, you should consult a doctor in time.