Generally speaking, vaccination is not recommended for patients who are in a febrile state, or suffering from acute diseases, in the acute exacerbation of chronic diseases, or serious chronic diseases that are not under control. While taking cold medicine in the morning, whether vaccination can be given in the afternoon needs to be analyzed specifically according to the specific development of the cold, which is generally divided into two cases: 1. Minor cold: If it is a minor cold without fever, vaccination can be given, but at this time the body resistance is relatively weak, and after vaccination, the increased reproductive power of attenuated viruses and bacterial pathogenesis may lead to the aggravation of cold symptoms and affect Therefore, it is necessary to closely observe the post-vaccination reactions after vaccination and reflect and deal with any discomfort in a timely manner. 2. Severe colds: If the body temperature is higher than 37.3℃ and the symptoms are heavy, vaccination is not recommended and vaccination should be carried out after the cold has healed for about a week. In addition, before vaccination, you should eat a light diet, try not to drink alcohol, do not eat spicy and stimulating food, pay attention to rest, do not stay up late, in order to maintain the best physical condition.