Moles up to 1cm in diameter are recommended to be removed by the patient, without removal there may be a risk of cancer. Nevus is a kind of pigmented nevus, which is a benign skin tumor of melanocyte origin. Generally, smaller nevi do not need special treatment. However, nevus with diameter up to 1cm will affect the patient’s aesthetics due to its large size, as well as easily rubbing with clothes or getting injured, and is prone to cancerous transformation. Therefore, patients with nevus up to 1cm in diameter often need to undergo surgical excision. In particular, nevi with a diameter of 1cm located in the palm and plantar area, waistline, armpit, groin, etc., should be considered for surgical excision because they are more susceptible to friction and injury than other locations, and have a higher risk of malignant transformation. After surgical excision, there is a possibility of recurrence, so care should be taken to protect the surgical site and avoid repeated friction. Therefore, patients with moles up to 1cm in diameter should go to the hospital in time for treatment under the guidance of a doctor.