The fastest way to recover from chest tightness and shortness of breath does not exist. Chest tightness and shortness of breath may be due to chronic obstructive pulmonary disease, pneumothorax, heart failure, reflux esophagitis, autonomic nervous system disorders, etc., which need to be treated with medication and surgery for the cause of the disease. 1. Chronic Obstructive Pulmonary Disease (COPD): Chronic inflammatory reaction of bronchial tubes leads to lung ventilation obstacle, so chest tightness and shortness of breath are obvious. Inhaled glucocorticosteroids such as budesonide and fluticasone, inhaled β1 agonists such as salbutamol and terbutaline, and inhaled cholinergic receptor blockers such as ipratropium bromide and tiotropium bromide should be used, together with the treatment of low-flow oxygen inhalation. 2. Pneumothorax: Chest wall trauma leads to rupture of the chest surface or rupture of the lung surface, and outside gas enters into the pleural cavity, continuously increasing the pressure in the pleural cavity and leading to chest tightness and shortness of breath. It is treated by chest puncture and pumping, closed chest drainage and so on. 3. Heart failure: due to the weakening of the pumping function of the heart, the pulmonary circulation is stagnant and the chest is stuffy and short of breath. Apply furosemide, hydrochlorothiazide, sodium nitroprusside, digoxin and other drugs to treat. 4. Reflux esophagitis: gastric acid and other gastric contents reflux into the esophagus when the lower esophageal sphincter is dysfunctional, irritating the esophageal mucosa, resulting in acid reflux, heartburn, chest tightness, shortness of breath and other symptoms. Apply drugs such as eplazole, omeprazole, domperidone, aluminum hydroxide and so on. 5. Autonomic disorder: sympathetic and vagal dysfunction leads to increased cardiac excitability, so chest tightness and shortness of breath. Take medicines such as ghrelin, methylcobalamin and metoprolol. Chest tightness and shortness of breath should be timely medical care, clear cause of the targeted treatment.