If hand numbness occurs frequently, you need to be alert to the following diseases: First, peripheral neuropathy, mostly multiple peripheral neuropathy, can involve both hands and feet, typically manifesting as glove or glove-like sensory abnormalities, with hyperalgesia more common, and may have a specific medical history such as diabetes, hyperlipidemia or uremia. Second, peripheral circulation disorders, if the patient has high blood viscosity, or has hyperlipidemia or hyperglycemia, even if no peripheral nerve injury lesion occurs, it may cause poor peripheral nerve blood supply and poor circulation leading to numbness, which is more common at night, and the symptoms can improve after waking up from sleep and activity. Third, cervical spondylosis, if there is a cervical disc herniation, compression of the nerve root may cause distal nerve dystrophy, prone to numbness, cervical magnetic resonance and upper limb nerve conduction velocity examination can help confirm.