The perianal warts can be topically applied with 0.5% tincture of pediculosis toxin, 50% trichloroacetic acid solution or 5% fluorouracil cream topically, or you can give retinoic acid cream with imiquimod cream topically. All of these drugs are irritating and must be used with care to protect the surrounding normal mucous membrane, and must be applied topically in small amounts, otherwise they can cause large ulcers or epidermal peeling. The rash also needs to pay attention to avoid contact with water and scratching to avoid aggravating the infection, and for smaller rashes it is best to first choose to undergo liquid nitrogen freezing treatment carbon dioxide laser treatment or electro-ionic cautery treatment. Because the skin around the anus is more moist, it is easy to adhere after using topical drugs, and you can also use immunomodulators, such as interferon, transfer factor, thymidine, etc.