Paroxetine and sertraline both belong to the selective 5-hydroxytryptamine reuptake inhibitors, these drugs have the role of treating premature ejaculation, and there is no significant difference in the therapeutic effect. These drugs are mainly to delay nerve conduction in the body, delay nerve excitation, so for premature ejaculation patients also have some therapeutic effect. This type of drug’s has some side effects. For example, nausea, vomiting, dizziness, abnormal erection of the penis and so on. Delayed ejaculation also belongs to one of the side effects, and some patients may not ejaculate with its use. This one side effect is utilized clinically to treat premature ejaculation. Overall, there are many causes of premature ejaculation, and it is recommended to go to a regular public hospital for examination and treatment after clarifying the cause.