Interferon therapy is recommended for minor triple positive patients according to their condition. Minor triple positive refers to those who are found to be positive for hepatitis B surface antigen, hepatitis B e antibody, and hepatitis B core antibody through hepatitis B two-to-one examination, which is an abnormal phenomenon, mostly suggesting that the replication of hepatitis B virus in the patient’s body is inactive, but still contagious, and the liver function of some patients may be impaired. Therefore, small triple sun patients need to actively cooperate with the doctor’s treatment, it is recommended to play interferon to control the body’s viral replication, such as ordinary interferon, polyethylene glycol interferon, etc., to promote the body to restore health. Before the use of interferon in patients with small triple yang, it is necessary to meet the indications for the use of the drug, such as high viral load of hepatitis B, abnormally high transaminases, liver damage has not reached the state of loss of compensation, and the patient’s mental state is good, and there is no family history of heredity or mental illness, and so on. If the conditions are not met, interferon therapy cannot be used. In addition to interferon, patients with small triple positive can also apply nucleoside analogs such as lamivudine, entecavir, tenofovir and other treatments as prescribed by the doctor, which can help to slow down the progression of the disease. Some patients can apply ursodeoxycholic acid, reduced glutathione and other drugs to protect the liver. It is recommended that the patients with small triple yang follow the doctor’s instructions to use medication, not to use drugs indiscriminately or choose folk remedies to treat the disease. Daily attention to appropriate physical exercise, more intake of nutritious food, help to strengthen the body, promote the body to restore health.